ICGEB Ph.D. course in Molecular Genetics

Molecular Biophysics

Outline:

This course is meant to provide an introduction to selected topics in protein research and will consist in lectures and journal club discussions. In the last course we heard about protein folding and protein NMR. The following topics includes network science as used in various fields of molecular biology. This course attempts to promote a holistic view that includes a wide range of approaches.  For further reading visit the virtual library.

Topics:

Roger H. Pain

U. Newcastle-J.Stefan Inst. Ljubljana:

 

PROTEIN FOLDING

Monday, November 17  (lecture)

1. Anfinsen and the protein folding problem (14:00-15:30)

2. How important are kinetics? (16:30-18:00)

 

Wednesday, November 26 , (lecture)

3. How does folding start? (14:00-15:30)

4. A new look at the Molten Globule (16:00-17:30)

 

Monday, December  1, (lecture)

5. Thermodynamics are not enough - the need for help (14:00-15:30)

6. Protein folding and disease (16:00-17:30)

 

           Lecture outlines and further reading

Alessandro Pintar

Protein Structure and Bioinformatics

ICGEB Trieste

 

PROTEIN NMR

 

Tuesday, December 2, 13:30-14:30, (lecture) Nuclear Magnetic Resonance in Structural Biology Lecture outline and further reading

 

Wednesday, December 10,  11:00-12:00 (Journal club, Elisa Tagliani, 1st year PhD student, Molecular Immunology Group ): Kim et al: A Zinc Clasp Structure TethersLck to T  Cell Coreceptors CD4 and CD8 (article)

 

Eivind Hovig

Dept. Tumor Biology and Bioinformatics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway

 

Monday, February 2, 13:30-14:30  Journal Club, Alejandro Palacios: Jenssen et al: Literature network of human genes, with some reference to Schlitt et al (links below)

 

Wednesday, February 11, 14:30 –16:00  "Development and use of literature networks in obtaining higher level biological information"

 

Further reading:  Jenssen et al, Nature Genetics, 2001, Schlitt et al, Genome Research, 2003

 

Janusz M. Bujnicki, Ph.D.

EMBO/HHMI Young Investigator, Laboratory of Bioinformatics and Protein Engineering International Institute of Molecular and Cell BiologyTrojdena 4, 02-109 Warsaw, POLAND

Monday, March 12, 14:30-16:30 "Introduction to protein structure prediction and modeling"

Lecture

Background reading

Albert-László Barabási, Emil t. Hofman Professor of Physics, Department of Physics, University of Notra Dame, IN 46556 USA.

 

Network biology, from protein interactions to antibiotics

 

Lecture: May 20, 12:00, ICGEB seminar room

 

Journal Club: 18 May, 12:00

Info

Barbara Argenti (Ext. 7333, bargenti@icgeb.org), Sándor Pongor (course organizer, ext 7300, pongor@icgeb.org)

 

Last modified: May 17, 2008.