STRUCTURAL BIOLOGY AND FUNTIONAL GENOMICS

 

E. Morton Bradury and Sándor Pongor

 

 

Kluwer Academic Publishers (1999)

 

 

 

 

 

Table of Contents.................................................................................................... v

 

Preface.................................................................................................................... vii

 

Acknowledgments................................................................................................... ix

 

 

1. The skeletal function of non-genic nuclear DNA: new evidence from ancient cell chimaeras

T. Cavalier-Smith and M. J. Beaton........................................................................ 1

 

2. DNA REPEATS IN THE HUMAN GENOME

Paolo Catasti, Xian Chen, S. V. Santhana Mariappan, E. Morton Bradbury and Goutam Gupta..................................................................................................................... 19

3. LEFT-HANDED Z-DNA: STRUCTURE AND FUNCTION

Alan Herbert and Alexander Rich.......................................................................... 53

 

4. SUPERHELICAL DNA STUDIED BY SOLUTION SCATTERING AND COMPUTER MODELS

Jörg Langowski, Markus Hammermann, Konstantin Klenin and Katalin Tóth.... 73

 

5. Micro-mechanical measurement of the torsional modulus of DNA

T.R.Strick, D. Bensimon and V. Croquette........................................................... 87

 

6. SEQUENCE-DEPENDENT MODELLING OF LOCAL DNA BENDING PHENOMENA: CURVATURE PREDICTION AND VIBRATIONAL ANALYSIS

Kristian Vlahovicek, Mircea Gh. Munteanu and Sándor Pongor........................... 97

 

7. MODELLING DNA STRETCHING FOR PHYSICS AND BIOLOGY

Richard Lavery and Anne Lebrun........................................................................ 115

 

8. SINGLE-CHAIN 434 REPRESSORS WITH ALTERED DNA-BINDING SPECIFICITIES: Isolation of mutant single-chain repressors by phenotypic screening of combinatorial mutant libraries

A. Simoncsits, M.-L. Tjörnhammar, S. Wang and S. Pongor............................... 133

 

9. Fast combinatorial cartography by FISH on combed genomic DNA

David Bensimon................................................................................................... 147

 

10. RNA FOLDING AND CATALYSIS

David M.J. Lilley................................................................................................. 151

 

11. HISTONE-DNA CONTACTS IN STRUCTURE/FUNCTION RELATIONSHIPS OF NUCLEOSOMES AS REVEALED BY CROSSLINKING

Sergei I. Usachenko and E. Morton Bradbury..................................................... 167

 

12. The role of histone H1 in chromatin condensation and transcriptional repression

Memmo Buttinelli, Gianna Panetta, Daniela Rhodes and Andrew Travers........ 191

 

13. CHROMATIN CONTROL OF HIV-1 GENE EXPRESSION

Giuseppe Marzio and Mauro Giacca.................................................................. 205

 

14. Mechanisms of separation of the complementary strands of DNA during replication

A.I. Alexandrov, N.R. Cozzarelli, V.F. Holmes, A.B. Khodursky, B.J. Peter, L. Postow, V. Rybenkov and A.V. Vologodskii..................................................................... 217

 

15. EXPLORING STRUCTURE SPACE: A Protein Structure Initiative

Thomas C. Terwilliger and Joel Berendzen......................................................... 235

 

16. The Protein Data Bank: Bridging the Gap Between the Sequence and 3D Structure World

J.L. Sussman, E.E. Abola, D. Lin, J. Jiang, N.O. Manning and J. Prilusky......... 251

 

17. FUNCTIONAL GENOMICS AND ENZYME EVOLUTION: Homologous and Analogous Enzymes Encoded in Microbial Genomes

M.Y. Galperin and E.V. Koonin.......................................................................... 265

 

18. THE BEAMLINES OF ELETTRA AND THEIR APPLICATION TO STRUCTURAL BIOLOGY

F. Zanini, A. Lausi and A. Savoia........................................................................ 285

 

Subject Index........................................................................................................ 303

 

Participants Lists................................................................................................. 307